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MOTS-c
What is MOTS-c?
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA type-c) is a small peptide that is derived from a mitochondrial protein. It was first discovered in 2015 and is still an area of active research.
MOTS-c is believed to have a variety of functions in the body, including regulating metabolism and mitochondrial function. It is thought to work by activating an enzyme called AMP-activated protein kinase (AMPK), which plays a key role in regulating cellular metabolism and energy homeostasis. Activation of AMPK can lead to increased glucose uptake, fatty acid oxidation, and mitochondrial biogenesis, all of which can improve cellular energy production and overall metabolic function.
MOTS-c has been studied for its potential therapeutic benefits in a variety of conditions, including metabolic disorders, cardiovascular disease, and aging-related conditions. Some studies have shown that administration of MOTS-c can improve insulin sensitivity and glucose metabolism, reduce inflammation, and protect against cellular damage.
What is Cellular Senescence?
When cells are damaged, they sense their damage, and they can pause. This process is called cellular senescence or cellular arrest. Cells are programmed to do this because they don’t want to replicate with damage. Instead, they pause until the immune system can clear them. Until cleared, senescent cells secrete signals that cause harm to the body. These signals increase inflammation, exhaust stem cells, and cause the body to age more rapidly. While senescence is natural, clearing senescent cells is vital to stop the aging process.
Indication:
- Decreases insulin resistance
- Better transport of sugars to muscle cells
- Fat loss
- More energy
- Greater resistance to metabolic stress
- Improved health and lifespan
